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The cardiovascular endpoint in the mice was also increased and this was more persistent than the increasing in HR which occurred following a single dose. A number of mechanisms may have underlain this dual effect of methyl chloride. The decrease in blood pressure may be attributable to methyl chloride-induced vasodilation. This process manifested within 60 minutes of exposure. Alternatively, the lowering of blood pressure may result from an inhibition of cardiac function (e.g., depression of cardiac output) and may be manifested within minutes. Inhibition of cardiac output and cardiac contractility is associated with central nervous system depression as reflected by decreasing in locomotor activity. Thus, the observed hypoactivity in this study can be associated with CNS depression. In conclusion, methyl chloride affects the cardiovascular system, and when exposed to animals, exerts cardiotoxic effects.
The mean dose (oral) of lindane at the time of analysis in the control and experimental animals was 8.3 mg/kg bw/day. Treatment of the rats with lindane induced a depletion in the serum insulin and total cholesterol levels as compared to the control group. These results suggest that lindane exposure may affect the carbohydrate metabolism and lipid profile of the exposed animals. The results of this study are in accordance with those observed by Dudley et al. (2002). Similar to lindane, albendazole also has the ability to influence the carbohydrate metabolism. d2c66b5586
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